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Istradefylline 40 mg/working day amplified peak levels and AUC of CYP3A4 substrates in clinical trials. This outcome wasn't observed with istradefylline 20 mg/working day. Look at dose reduction of sensitive CYP3A4 substrates.Modafinil appears to be Secure for extended intervals at average (one hundred–two hundred mg) each day dosages, and enormo